Replies to your campaigns
A sender profile has a Reply-To (optional) field. Set it when replies should go somewhere other than the from-address — sending from news@ while replies land in a support inbox is the usual case.
Leave it empty and replies go to the From Email.
Replies arrive in your own mailbox
They are ordinary email to the address you configured, not something collected in this dashboard. So the address you set must be one somebody actually reads.
That is the failure worth avoiding: a Reply-To pointed at an inbox nobody monitors is worse than none, because customers reply believing they have reached you.
Why replies are worth encouraging
Beyond the obvious. Replies are one of the strongest positive signals a mailbox provider can see — a person writing back is unambiguous evidence the mail is wanted, in a way an open never is.
A campaign that asks a question and gets answers helps your delivery as well as your relationships. See Landing in the inbox instead of spam.
So avoid noreply
noreply@ addresses throw away that signal and frustrate people who have a genuine question. If you cannot monitor the from-address, set Reply-To to one you can.
Replies are not unsubscribes
Someone replying "please stop emailing me" has not unsubscribed — nothing automatic happens to a reply. Suppress them manually, using Manually suppress an email on the Suppressions page, or they will receive the next campaign and quite reasonably mark it as spam. See The suppression list.
Next: open Senders, check the Reply-To on your default profile, and confirm somebody reads that inbox.
Related articles
Ask Agent PK in your dashboard
Agent PK answers from these same articles, looks at your own account, and can do the task for you once you confirm. Open it from the top bar in the dashboard.